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Computation of Conditional Power: A Case Study of Oncology Phase- II Clinical Trial
Rajneesh Singh1, Rakesh Kumar Saroj2*, K. H. H. V.S.S. Narasimha Murthy2#

Published in: Journal for Advance Research in Applied Sciences
Volume- 4, Issue-7, pp.70-78, Dec 2017
DPI :-> 16.10089.JARAS.2017.V4I7.7078.2222



Abstract
Objective of this paper is to explain the conditional power (CP) through a case study which is a single arm, two stages, and oncology phase –II with the sample size of 63 patients. In first stage we have enrolled 23 patients these were followed for a year. Based on stages – I study data, we need to plan whether study will continue in stage –II for remaining 40 patients i.e. 63-23 = 40 (63 patients are sample size in which 23 patients have been enrolled and followed up for a year in stage -I). Through conditional power which is a frequentist approach it can give a direction for taking decision whether study will continue or not. The estimation of conditional power (CP) is based on Z-statistic, Kaplan Meier (KM) survival probability and presumed survival probability of study treatment. A confident result is obtained from this study data. The computed conditional power is more than 80% which give a confidence for continuation of study in next stage. A conditional power (CP) from stage –I data is playing a very vital role to assess the decision for continuation of study in next stage i.e. stage –II. However, apart from conditional power (CP), the clinical investigator decision on safety issues and their statistical proof provide the essential evidence to make a conclusion that whether study will carry on to the next stage or it will be stopped in existing stage

Key-Words / Index Term
Conditional Power (CP), Predictive Power (PP), Kaplan Meier (KM)

How to cite this article
Rajneesh Singh1, Rakesh Kumar Saroj2*, K. H. H. V.S.S. Narasimha Murthy2# , “Computation of Conditional Power: A Case Study of Oncology Phase- II Clinical Trial”, Journal for Advance Research in Applied Sciences, 4, Issue-7, pp.70-78, Dec 2017. DPI:16.10089.JARAS.V4.I7.2222