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THE SYNTHESIS AND EVALUATION OF COMBINE DRUG ACTION OF CODEINE AS SUPPLEMENTARY DRUG WITH DAKIN-WEST ?-ACETAMIDOKETONES
Rameshwar S. Dhamak, Deepak. M. Nagrik, Shrikant S. Patil

Published in: International Journal of Current Engineering And Scientific Research ( IJCESR)
Volume- 5, Issue-1, pp.51-56, Jan 2018
DPI :-> 16.10046.IJCESR.2018.V5I1.5156.2315



Abstract
?-acetamido ketones were synthesized in high yields under mild condition via four component Dakin-West reaction which carried out by condensation of aromatic aldehydes, enolizable ketones, acetonitrile and acetyl chloride in presence of mixed metal oxide CuO-SnO2 as versatile catalyst. The biological study of compounds codeine was used as supplementary drug in combination of the resultant Dakin-West compounds. Interesting results were obtained in accordance with the principle of ‘Synergism’. It was observed that, synthesized ?-acetamidoketones and supplementary drug, Codeine worked together to produced results which were not independently obtainable

Key-Words / Index Term
Combine drug action, DakinWest reaction, Synergism, Supplementary drug, Codeine

How to cite this article
Rameshwar S. Dhamak, Deepak. M. Nagrik, Shrikant S. Patil , “THE SYNTHESIS AND EVALUATION OF COMBINE DRUG ACTION OF CODEINE AS SUPPLEMENTARY DRUG WITH DAKIN-WEST ?-ACETAMIDOKETONES”, International Journal of Current Engineering And Scientific Research ( IJCESR), 5, Issue-1, pp.51-56, Jan 2018. DPI:16.10046.IJCESR.V5.I1.2315